Leonard Peikoff provides a detailed analysis and concretization of the principles that everything in the universe is interrelated, and that every item of knowledge is connected to every other.  Peikoff sets out the Objectivist view of unity and applies it to metaphysics before discussing a concrete example to elucidate the principle in epistemology. He argues, by way of his own experience with rationalism, that integration is a key component to human cognition.